SubstancesSubstances of very high concern

Cyclosiloxanes (D4, D5, D6)

The cyclic volatile methylsiloxanes D4, D5 and D6. They are persistent and bioaccumulative, sit on the REACH Candidate List, and face restrictions in wash-off cosmetics under Annex XVII.

Updated
2026-06-12

Overview

The cyclosiloxanes are a small family of volatile silicone ring molecules. The three of regulatory interest are D4 (octamethylcyclotetrasiloxane), D5 and D6. They evaporate readily, which makes them useful in cosmetics and cleaning products and as feedstock for silicone polymers. The same volatility, combined with their persistence and tendency to accumulate in living things, is what drives concern.

D4 CAS
556-67-2
D5 CAS
541-02-6
D6 CAS
540-97-6
Why restricted
Persistent and bioaccumulative
Typical use
Cosmetics, cleaning products, silicone polymers

Where they're restricted

All three are on the REACH Candidate List as substances of very high concern. Under REACH Annex XVII they are already restricted in wash-off cosmetic products, such as rinse-off shower gels and shampoos, where the material is washed down the drain after use. Broader restrictions covering more product types are under discussion.

Key point

D4, D5 and D6 are flagged for being persistent and bioaccumulative rather than for acute toxicity. The worry is long-term build-up in the environment, not immediate harm.

Typical uses

These siloxanes feature in personal care and cosmetic formulations, in some cleaning products, and as building blocks for the silicone polymers used across many industries. Reformulation away from the cyclic forms is ongoing in consumer products.

Note: general educational information, not legal advice. Check the official source before relying on it.

Learn 4 flashcards

Related entries

SVHCREACHPBTcosmetics